A long standing goal in neuroscience has been to elucidate the functional organization of the brain. Within higher visual cortex, functional accounts have remained relatively coarse, focusing on regions of interest (ROIs) and taking the form of selectivity for broad categories such as faces, places, bodies, food, or words. Because the identification of such ROIs has typically relied on manually assembled stimulus sets consisting of isolated objects in non-ecological contexts, exploring functional organization without robust a priori hypotheses has been challenging. To overcome these limitations, we introduce a data-driven approach in which we synthesize images predicted to activate a given brain region using paired natural images and fMRI recordings, bypassing the need for category-specific stimuli. Our approach - Brain Diffusion for Visual Exploration ("BrainDiVE") - builds on recent generative methods by combining large-scale diffusion models with brain-guided image synthesis. Validating our method, we demonstrate the ability to synthesize preferred images with appropriate semantic specificity for well-characterized category-selective ROIs. We then show that BrainDiVE can characterize differences between ROIs selective for the same high-level category. Finally we identify novel functional subdivisions within these ROIs, validated with behavioral data. These results advance our understanding of the fine-grained functional organization of human visual cortex, and provide well-specified constraints for further examination of cortical organization using hypothesis-driven methods.

Sparse longitudinal (SL) textual data arises when individuals generate text repeatedly over time (e.g., customer reviews, occasional social media posts, electronic medical records across visits), but the frequency and timing of observations vary across individuals. These complex textual data sets have immense potential to inform future policy and targeted recommendations. However, because SL text data lack dedicated methods and are noisy, heterogeneous, and prone to anomalies, detecting and inferring key patterns is challenging. We introduce LLmFPCA-detect, a flexible framework that pairs LLM-based text embeddings with functional data analysis to detect clusters and infer anomalies in large SL text datasets. First, LLmFPCA-detect embeds each piece of text into an application-specific numeric space using LLM prompts. Sparse multivariate functional principal component analysis (mFPCA) conducted in the numeric space forms the workhorse to recover primary population characteristics, and produces subject-level scores which, together with baseline static covariates, facilitate data segmentation, unsupervised anomaly detection and inference, and enable other downstream tasks. In particular, we leverage LLMs to perform dynamic keyword profiling guided by the data segments and anomalies discovered by LLmFPCA-detect, and we show that cluster-specific functional PC scores from LLmFPCA-detect, used as features in existing pipelines, help boost prediction performance. We support the stability of LLmFPCA-detect with experiments and evaluate it on two different applications using public datasets, Amazon customer-review trajectories, and Wikipedia talk-page comment streams, demonstrating utility across domains and outperforming state-of-the-art baselines.

Multivariate longitudinal data of mixed-type are increasingly collected in many science domains. However, algorithms to cluster this kind of data remain scarce, due to the challenge to simultaneously model the within- and between-time dependence structures for multivariate data of mixed kind. We introduce the Mixture of Mixed-Matrices (MMM) model: reorganizing the data in a three-way structure and assuming that the non-continuous variables are observations of underlying latent continuous variables, the model relies on a mixture of matrix-variate normal distributions to perform clustering in the latent dimension. The MMM model is thus able to handle continuous, ordinal, binary, nominal and count data and to concurrently model the heterogeneity, the association among the responses and the temporal dependence structure in a parsimonious way and without assuming conditional independence. The inference is carried out through an MCMC-EM algorithm, which is detailed. An evaluation of the model through synthetic data shows its inference abilities. A real-world application on financial data is presented.

Motivation. Understanding the pan-cancer mutational landscape offers critical insights into the molecular mechanisms underlying tumorigenesis. While patient-level machine learning techniques have been widely employed to identify tumor subtypes, cohort-level clustering, where entire cancer types are grouped based on shared molecular features, has largely relied on classical statistical methods. Results. In this study, we introduce a novel unsupervised contrastive learning framework to cluster 43 cancer types based on coding mutation data derived from the COSMIC database. For each cancer type, we construct two complementary mutation signatures: a gene-level profile capturing nucleotide substitution patterns across the most frequently mutated genes, and a chromosome-level profile representing normalized substitution frequencies across chromosomes. These dual views are encoded using TabNet encoders and optimized via a multi-scale contrastive learning objective (NT-Xent loss) to learn unified cancer-type embeddings. We demonstrate that the resulting latent representations yield biologically meaningful clusters of cancer types, aligning with known mutational processes and tissue origins. Our work represents the first application of contrastive learning to cohort-level cancer clustering, offering a scalable and interpretable framework for mutation-driven cancer subtyping.

Clustering patient subgroups is essential for personalized care and efficient resource use. Traditional clustering methods struggle with high-dimensional, heterogeneous healthcare data and lack contextual understanding. This study evaluates Large Language Model (LLM) based clustering against classical methods using a pediatric sepsis dataset from a low-income country (LIC), containing 2,686 records with 28 numerical and 119 categorical variables. Patient records were serialized into text with and without a clustering objective. Embeddings were generated using quantized LLAMA 3.1 8B, DeepSeek-R1-Distill-Llama-8B with low-rank adaptation(LoRA), and Stella-En-400M-V5 models. K-means clustering was applied to these embeddings. Classical comparisons included K-Medoids clustering on UMAP and FAMD-reduced mixed data. Silhouette scores and statistical tests evaluated cluster quality and distinctiveness. Stella-En-400M-V5 achieved the highest Silhouette Score (0.86). LLAMA 3.1 8B with the clustering objective performed better with higher number of clusters, identifying subgroups with distinct nutritional, clinical, and socioeconomic profiles. LLM-based methods outperformed classical techniques by capturing richer context and prioritizing key features. These results highlight potential of LLMs for contextual phenotyping and informed decision-making in resource-limited settings.

Clustering scientific publications can reveal underlying research structures within bibliographic databases. Graph-based clustering methods, such as spectral, Louvain, and Leiden algorithms, are frequently utilized due to their capacity to effectively model citation networks. However, their performance may degrade when applied to real-world data. This study evaluates the performance of these clustering algorithms on a citation graph comprising approx. 700,000 papers and 4.6 million citations extracted from Web of Science. The results show that while scalable methods like Louvain and Leiden perform efficiently, their default settings often yield poor partitioning. Meaningful outcomes require careful parameter tuning, especially for large networks with uneven structures, including a dense core and loosely connected papers. These findings highlight practical lessons about the challenges of large-scale data, method selection and tuning based on specific structures of bibliometric clustering tasks.

We consider generating post-hoc explanations of clusters generated from various datasets using auxiliary information which was not used by clustering algorithms. Following terminology used in previous work, we refer to the auxiliary information as tags. Our focus is on two forms of explanations, namely disjunctive form (where the explanation for a cluster consists of a set of tags) and a two-clause conjunctive normal form (CNF) explanation (where the explanation consists of two sets of tags, combined through the AND operator). We use integer linear programming (ILP) as well as heuristic methods to generate these explanations. We experiment with a variety of datasets and discuss the insights obtained from our explanations. We also present experimental results regarding the scalability of our explanation methods.

As social robots and other artificial agents become more conversationally capable, it is important to understand whether the content and meaning of self-disclosure towards these agents changes depending on the agent's embodiment. In this study, we analysed conversational data from three controlled experiments in which participants self-disclosed to a human, a humanoid social robot, and a disembodied conversational agent. Using sentence embeddings and clustering, we identified themes in participants' disclosures, which were then labelled and explained by a large language model. We subsequently assessed whether these themes and the underlying semantic structure of the disclosures varied by agent embodiment. Our findings reveal strong consistency: thematic distributions did not significantly differ across embodiments, and semantic similarity analyses showed that disclosures were expressed in highly comparable ways. These results suggest that while embodiment may influence human behaviour in human-robot and human-agent interactions, people tend to maintain a consistent thematic focus and semantic structure in their disclosures, whether speaking to humans or artificial interlocutors.

Generating multiple counterfactual explanations for different modes within a class presents a significant challenge, as these modes are distinct yet converge under the same classification. Diffusion probabilistic models (DPMs) have demonstrated a strong ability to capture the underlying modes of data distributions. In this paper, we harness the power of a Diffusion Autoencoder to generate multiple distinct counterfactual explanations. By clustering in the latent space, we uncover the directions corresponding to the different modes within a class, enabling the generation of diverse and meaningful counterfactuals. We introduce a novel methodology, DifCluE, which consistently identifies these modes and produces more reliable counterfactual explanations. Our experimental results demonstrate that DifCluE outperforms the current state-of-the-art in generating multiple counterfactual explanations, offering a significant advance- ment in model interpretability.

Multi-objective reinforcement learning (MORL) is used to solve problems involving multiple objectives. An MORL agent must make decisions based on the diverse signals provided by distinct reward functions. Training an MORL agent yields a set of solutions (policies), each presenting distinct trade-offs among the objectives (expected returns). MORL enhances explainability by enabling fine-grained comparisons of policies in the solution set based on their trade-offs as opposed to having a single policy. However, the solution set is typically large and multi-dimensional, where each policy (e.g., a neural network) is represented by its objective values. We propose an approach for clustering the solution set generated by MORL. By considering both policy behavior and objective values, our clustering method can reveal the relationship between policy behaviors and regions in the objective space. This approach can enable decision makers (DMs) to identify overarching trends and insights in the solution set rather than examining each policy individually. We tested our method in four multi-objective environments and found it outperformed traditional k-medoids clustering. Additionally, we include a case study that demonstrates its real-world application.